What's more, testosterone plays other important roles in health and disease that may surprise you. On the other hand, correcting a true nutrient deficiency can improve hormone levels and well-being. Investigation helps separate reversible causes—poor sleep, medication side effects, uncontrolled chronic disease—from hormone deficiency that needs targeted care. A clinician typically starts with a blood measure of total testosterone taken in the morning and repeats it to confirm low values. Cortisol is a hormone that works against your testosterone. A consistent lack of good-quality sleep can also lead to weight gain, which can reduce your testosterone production. Sleep is essential for your good health, and it affects your testosterone. One way the body regenerates the ATP to give you bursts of energy is through the creatine stored in your body as phosphocreatine. You also get creatine when you eat animal-based protein, such as red meat, seafood and poultry. But the increases in T were small—between about 0.6 ng/mL 1.5 ng/mL—and the subjects’ T levels were ultimately still well within normal ranges. For most people, creatine offers performance benefits without negative effects on hormonal balance. Unlike anabolic steroids or hormone therapy, creatine works by fueling energy systems in the muscles, not by directly altering endocrine function. If someone is experiencing fatigue, reduced muscle mass, or other symptoms of clinically low testosterone, they should consult a healthcare professional. Therefore, more research is needed to understand the potential benefits of beta-alanine supplementation. While these products can help you consume more calories, there’s nothing magical about weight gainer supplements. Although the calorie contents of weight gainer supplements vary, it’s not uncommon for some to contain more than 1,000 calories per serving. If you’re experiencing symptoms like erectile dysfunction or depression, talk with a doctor before trying testosterone boosters. Research on testosterone boosters is inconclusive, but some ingredients may be beneficial. Your doctor can prescribe testosterone therapy as part of gender-affirming treatment. There aren't studies to back up using it for other symptoms.